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Stress and Aggression P4

Looking at the relationship between stress and GABA levels, again, the impact that stress has on dopamine and norepinephrine levels. Stress and aggression, stress playing a role with glutamate.  Again, if you do not do anything else, just get the stress and glutamate balance not only for your children but for yourself.

The level of stress exacerbates MS in adults.  Glutamate is going to increase reactive oxygen species. So, that ties together with the talk we had earlier on NOS, and if we don’t have sufficient levels of BH4, we have reactive oxygen species.  So, glutamate is also going to add to that picture and an increase in some of the key inflammatory mediators.

So, lead is going to exacerbate some of these problems.  Some of the types of formulas that we use to address this pathway, trying to keep stress in balance, deal with inflammation, deal with cytotoxin issues and deal with the mental imbalance.

Again, stress causes the shift from TH1 to TH2.  That’s going to be an inflammatory response and a lot more humeral response so a lot more B cells. Maybe where some of those antibodies are coming from.  Cellular immunity which is the T cells, we’re going to have a little bit more trouble with those T cells because we don’t have enough building blocks for new T cell synthesis, but also, if the stress is shifting us to a B cell response, we’re moving away from the regulatory T cell and T cell response.  We have a lack of building blocks to make the T cells we need.

Again, stress is really causing a major shift in the TH1, TH2 patterns, increasing cytokines.  Cytokines we talked about earlier with microglial activation causing inflammation as well as susceptibility to disease.  Lack of BH4 can cause mast cell degranulation, and one of the particular slides in this presentation showed you that mast cell degranulation leads to that release of histamine that’s tied to aggression.  Again, another place where BH4 plays a role and another good reason to look at having sufficient BH4 in the system.

Stress has an effect on infection as well as wound healing.  Again, wound healing will have an impact on your methylation cycle because you need the building blocks to make new cells.  Stress is stressful. You’re going to be more likely to have chronic viral infections with stress, and we’re already trying to address this chronic virus in the matters we can.  We’ll talk about that more tomorrow.  Upper respiratory infections and colds are more of a problem with stress.

Stress triggers IL-1, one of the key inflammatory mediators that I pointed out to your earlier today.  Also, IL-6 and stress triggers levels of IL-6.  So, it’s no surprise that when you’re under constant stress, you don’t feel good.  You’re not well.  You’ve got inflammation in your body, and you’re more likely to be sick, to be depressed and have negative consequences.

So, if we look at the tie in between bacterial infections, we already said that chronic viral infection increases stress. We see, again, this cascade with MAP-38 kinase that ties in that protein kinase C and aggression, high levels of IL-6.  Remember, without adequate methylation, we can’t remyelinate the nerves. Again, IL-6 and stress.

Chronic stress is like a house of cards. This can all fall apart pretty easily.  We talked earlier about the matrix metaloproteinases that are upregulated in autistic individuals as well as the levels of IL-6 and TNF-alpha, IL-6, and NF-kappa-B.  Again, VEGF is tied in with the progression of cancer and tumors.  So, when you have problems in your TH1 to TH2 shift, you start to see the kind of magnitude of response you have going on in the body, the type of damage this can cause, and the drain on the body for the repair to fight that damage.  This is the map of how connected TNF-alpha is.  So, once you’ve got the levels of TNF-alpha up from an inflammatory cascade or infection, you’re triggering inflammatory responses all over the body.

Needless to say, stress has an impact on your immune system and also the whole mind-body conversation.  During the break, I had an interesting conversation with someone who came to the conference today, and this is a good moment to reiterate the effect that spirituality and mind can have on health and wellness and healing. I know in our autism answer site, we have one of the forms of prayer, and all of you know that I pray for the children I work with every single day, but also to put out positive message, positive affirmations, positive feedback.

What this individual was telling me was before she used the RNA, she actually holds them in her hand and thinks good things and positive things and love before she administers it, and it only takes a few minutes to do something like that.  You certainly have nothing to lose even if it’s not in your list of things you might believe in, but there is a connection known between the mind and how it affects the body.  It’s actually mediated by these key inflammatory mediators.  So, one of the reasons why on the autism answer site I’m so insistent about no negativity to help people, why I sign everything with love and hope, and I really mean that, and why I want everyone to pay it forward because I think that with the right mindset as well as all the medical tools will help to the place that we need to be.  It’s always nicer to do it by helping each other.

Stress affects memory.  We’ve all experienced that, testing in schools.  The higher levels of cortisol, even though they help us to modulate that stress effect, can hurt us in terms of learning and memory.  I know my own girls have always found that phosphatidyl serine which helps to modulate cortisol levels really helps them with their memory before test in school because stress will trigger that memory loss.  So, stress and memory.  We see the tie in between a mediator and aggression as well as stress that may be playing a role in impairing memory.  Stress early in life can affect your memory later in life. Stress can play a role in attention, and, again, high levels in norepinephrine can trigger on attention and behavior.

Inflammation and stress can play a role in hypertension as well as metabolic syndrome, and this inflammatory triggered by stress plays a role in numerous conditions, whether it’s diabetes, whether it’s heart disease, whether it’s cancer, low blood sugar.

What can we do about some of this?  Well, looking at your diet as Dr. Gordon talked about earlier makes a big difference because stress will make you gain weight.  Stress is really a major culprit in the system, especially abdominal weight gain. Work-related stress plays a role in weight gain as well as that pain.  Work stress and the effect it can have on infection. I think when we’re talking about work, it’s no different than the work of a caregiver for your children.  So, whether we’re talking about infection, whether we’re talking about weight gain, whether we’re talking about aggression, inflammatory process, back pain, or atherosclerosis, heart disease, stress is playing a role with all of these. It’s mediating it’s effects with epinephrine and norepinephrine, and every time we see that, we’re drawing methyl groups from other important aspects of our body. Also, vascular function, heart function, and, again, I’ve gone through these more slowly in the past.

Even skin conditions.  Inflammatory skin conditions are exacerbated by stress. Sometimes, we’ll see posts where parents are talking about rashes that kids are getting. Part of that is the detox rash.  How much of it is triggered by the stress on the system of detox and the inflammatory cascades is hard to separate. What we do about it is still the same thing, but keep in mind that it is relate.  Even the relationship between psoriasis and the methylation cycle.  So, we really can’t separate what’s going on in the methylation cascade from some of what’s going on physically if we’re looking at skin conditions.

Stress also plays a role in fertility, and I know I was talking with some of the moms during the break about the type of supplementation or if you’re looking to have more children, look to supplement.  Also, keep in mind the effect of stress on your system, getting pregnant as well as development.  Stress and inflammation is a disease of aging and all the diseases that can occur as a result of chronic inflammation triggering your body by chronic infection as well as stress.

Stress may shorten your life by pruning DNA.  So, now, we’re back in a molecular level that it may be that stress directly affects DNA levels, and stressed to death that mental stress affects your life span.  We already talked about the relationship of stress and cancer.  Again, stressful conditions will cause that.

Now, how do we address this?  I already mentioned phosphatidyl serine.  Phosphatidyl serine helps us to control cortisol in the body.  Other things that we can look at in terms of stress would be things like rude ola, muscle support RNA, stress support RNA.  In using DMG to balance the system, DMG will help us to slow down the BHMT enzyme, the back door, which is why early on, I don’t want to use DMG because I want to get that shortcut working. Once we have it working, we look to tone it down and make that shift to the long way around the pathway with DMG and SAMe.  Again, DHMT is right here, early on in this.  Overtime, with DMG and SAMe, we look to get through the MTR and MTR pathway.

Again, look at the diet you’re eating.  Go out in nature.  It sounds a little bit trite, but just going for a walk or taking a break will make a difference.  Humor makes a tremendous difference in lowering stress as well as helping your immune function. Even your natural killer cell activity can be naturally increased.

Magnesium we’ve already talked about, and the role of magnesium in substance P as well as serotonin levels. A pet, although that’s extra stress, it does put it over the top.  Art, music, as well as just finding 5 minutes to take a break and think positive because positive thoughts make a big difference.

As I’ve said so many times before, what we’re doing is a marathon.  Erin mentioned to you earlier she and I have been working together for four years.  Her boys aren’t 100%, but they’re most of the way there.  Some children recover in six months. Some are going to take four years.  Some will take five years.  It’s a marathon, and it’s also a rollercoaster ride when we’re having detox.  When you’re getting the black lines across the page, are you at the top or the bottom of the roller coaster?  It’s a little hard to say, but you really need to pace yourself and not be in a rush because it’s a long haul.  I’m not going anywhere. I’m on the other side of the keyboard.  We’re getting the information about there, and really, it’s about taking a deep breath and pacing yourself for it.

This is a quote from Dr. Valerie Hunt: “When one represses emotion, one’s body hurts; when one represses consciousness, one’s mind aches; when one represses spirituality, one’s soul hurt.” So, again, keeping in mind the whole mind, body, spirituality that follows this and helping to get back balance, recovery, and getting through the process.

I really do believe with belief, with hope, and with a knowledge of molecular pathways, we really can make a difference and help to recover every child and adult.  Thank you.


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