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Holistic Health & Nutrigenomic Profiling P6

You don’t even have to understand what these gels me but a housekeeping gene which stays even, no matter what,  this one that has been looked at with respect to autism now is highly regulated by methylation, okay.  And when we  look at what are we talking about when we talk about a voltage gated calcium channel moving back-and-forth across that membrane looks a lot like what I just showed you happens in the membrane of the mitochondria to generate that energy to drive that, to opening close for calcium, okay.   Also recall the role of calcium in seizure activity.  If we don’t have the calcium  handled  properly, we run the risk of seizure activity in addition to the role aluminum plays  and estrogen we’ll talk about that in the minute. And so glutamate is the gun and calcium is the bullet.  If we have the combination between glutamate and calcium we are  going to have problems, we are going to have membrane damage and over excitation at some of the receptors.  And basically what’s going on when that happens, well we have overstimulation and then we can’t recover.  That’s what we’re talking about we talk about excitotoxin damage. Okay,  so we’ve talked about the role of estrogen, calcium, how glutamate is involved, how aluminum ties  back to whether it’s glutamate, whether it’s reactive oxygen species, held onto with the bacteria, and then the snips that can play a role in increasing this bacterial load.  So now let’s take a minute and look at the connection between aluminum and estrogen and seizure activity.

And so when aluminum is added to the system, whether it’s an individual who is accidentally exposed to it or some of the animal models we’ll look at in a minute, it increases seizure activity. And again using aluminum cream in experimental models causes temporal lobe epilepsy and seizure activity. And again looking at the threshold that’s needed with aluminum to create epilepsy and seizure activity, okay.

 

 

So if you look at these  are animal models and the amount of the cream and the number and the increasing seizure activity.

Okay and so there’s a quantitative threshold  for epilepsy in monkeys that’s created simply by adding aluminum. Okay.

And we can look at what’s physically going on in the brain, we can look at..aahm… EEGs to see what’s going on, and we can look at the list of symptoms that occur due to aluminum toxicity in the system and seizure and epilepsy that occurs. [01:16:14.12] And I know we’re short on time to get through all this material so I’m not going to read through it but you can look at the slides later and you’ll be amazed at the correlation between a lot of the symptoms that you might be seeing in your own children and the list of what can occur due to do aluminum toxicity.

Now estrogens have been played as the good guy as well as the bad guy in seizure activity, and the bottom line with almost anything is moderation. Okay.  And so we can look at the effect  estrogen has on the system and in low doses  it is in fact protective and so we can conclude that estrogen… the effect is complex. You want to look at them individually and we want to see where and when it makes sense to support with even estrogenic herbs and  in a minute we’re gonna  look at the PMT snip, and I’ll give you some clues as to when we’re seeing calcium disregulation, imbalances in the lipids in the membrane, and where those maybe individuals who might be more prone to seizure activity, and maybe where you want to use something like Don quai  and black cohosh to support…aahm.. in a healthy safe manner some of those herbs.

Also when testosterone modulates seizure activity it is doing so through an estrogen pathway. And so looking at the anti-seizure effects also of progesterone – so whether you’re using a balance of estrogenic herbs and progesterone cream and trying to keep the system in balance with respect to seizure activity. And you can see that the number of partial and full seizures can be adjusted simply based on the amount of progesterone used in the system. Okay, so to review before we get into some specifics of what bacteria you have. How do you know which ones you have.  How do we address them? and how do we get this aluminum out of the body as well as some of the other heavy metals?

Certain snips can predispose to chronic bacterial issues.

Bacteria can hold onto metals.

Aluminum can play a role in seizure activity and inhibit mitochondrial function as well as increased oxidative stress. The opposite side of mitochondrial energy is this oxidative stress, how it affects BH4 levels, how important BH4 levels are, and the Catch-22 between aluminum decreasing BH4 levels and thinking about when we want to address  anaerobes with something like hyperbaric oxygen in the scheme of things so that we have this first part under control. And the role estrogen may play in being somewhat protective for calcium regulation as well as glutamate induced seizure activity.

 

There’s a tight correlation between boron levels and hormone levels in the body. And when we look at a lot of the adults on the site at this point we see significant drops in boron levels in postmenopausal women. [01:19:37.08]

Also, coincidentally, SAMe holds onto boron very tightly. So as part of the problem with boron retention in the body that as we age and the methylation cycle intermediates decrease and we are not supporting to bypass those mutations that we’re less able to hold onto the boron that the system needs.  If we don’t have enough boron it impacts on the methylation cycle and homocysteine levels.  So it looks like there’s a complex relationship between boron, estrogen, SAMe and methylation cycle.

And when we have high levels of lead and cadmium we often see drops in strontium and boron and calcium can drop. Some of this is very subtle like the iron on data that I showed you earlier and so what you’re looking for, and this is subtle, but when you’re seeing cadmium and lead, you are looking  to see if boron is to the left of 50% okay.

And again even low doses of cadmium  and lead, the boron levels start to drop, alright.

Okay, so you’re looking at that drop in boron,  and when you look at the UEEs  you want to pay careful attention. It might be tempting to ignore this but if you’re seeing cadmium and lead excretion, and you’re starting to see a drop in boron, pay attention.  Think about supplementing.  Think of the role of boron and the inter-relationship with SAMe, The relationship to the estrogen and what we just finished talking about,  about estrogen being protected…in the system for oxidative damage on as well as seizure activity.

Some of the newer snips that were looking at is PEMT enzyme,  and how this ties in – PEMT sits at a critical juncture here. It’s very important in the generation of some of the phospholipids in the membrane that we look at on  a UEE. It’s sitting at a point in the cycle that’s affected by SAMe. Boron homocysteine levels being affected by boron, so it’s right in the middle of this interacting sphere that we just finished talking about.

Women with a particular PEMT variant have increased risk of organ dysfunction, especially if you’re not supporting that methylation cycle.  It’s important in helping to make the choline ______ so when we look at phosphatidylcholine, phosphatidylserine, phosphatidyl ________[01:22:28.16] the support that we’re using  for the shortcut through the cycle through that  PEMT enzyme. This is playing a role, which is why we’ve added in the snip, and it’s possible that this PEMT enzyme, it alters and affects the way estrogen plays role in the system. Okay.  And so this PEMT enzyme is induced by estrogen in the body. And so when we have people who have mutations in this pathway. Fatty liver issues may tie into some of those fatty acids we looked at. The need for digestive enzymes that swampy gut that we take a look at in a short chain fatty acids. And so adding in, layering in this other factor PEMT, the role it plays with fatty acid metabolism, the role it may be playing with respect to estrogen, the role of estrogen on aluminum toxicity, oxidative stress, seizure activity.  Okay.  So  PEMT activity’s  affected by estrogen. It’s part of the same pathway we just looked at that’s also in turn affected by estrogen and boron,  and it increases… it decreases signaling through a part of the pathway that we’ve looked at before for autism okay.

So PEMT decreases signaling in a portion and these are slides we have seen before. [01:24:05.21]

 

So when we are looking at myelination, when we are looking at long-term potentiation and memory, when we are looking at what’s happening at particular areas of the brain, that can be affected in autism, this intermediate in the pathway is in fact affected directly by that enzyme activity.

 

And so we’re looking at the effect that this may have and the fact that there may be high activity  of P13K in autism yet,  let’s go back the second,  PEMT down regulates it, [01:24:52.16]  PEMT is affected by estrogen levels, and so looking at the effect of this snip in the body, the role of estrogen, the role this may play relative to calcium regulation. The recent finding of the role of that voltage gated calcium channel, how it affects mitochondria, the energy, the estrogen, signaling and the increased signaling of this intermediating autism.

And again just looking at the complexity of this pathway the role of calcium the role of glutamate, the memory this intermediate and then how PEMT affects and regulates and down regulates over activity. So what we do about it? How do we look at it? The new snips that are on the panel are looking at two particular PEMT snips and this is one particular individual that showing a pattern where we’re in the process of defining what a plus minus, what a plus plus, what these mean in terms of the biochemical tests we look at.  But he is minus minus and plus plus. What we see over time is, with no calcium support, so we’re not supporting calcium. [01:26:08.03]

This child tends to have high calcium levels and remember we’ve just finished talking about the role of estrogen in controlling calcium. The role of that voltage gated calcium channel. The role PEMT plays and how it may be regulated by estrogen and now with a particular snip pattern were seeing high calcium even though we’re not adding any calcium. And I know that if calcium is higher than magnesium I’m going to have a problem with potential seizure activity and excitotoxin damage.

The other piece that we see with that pattern is low phospholipids.  And remember I told you a few moments ago PEMT is critical in that pathway of phosphatidylcholine Fossetts 11 Nolan he phosphatidylserine.  And so what I would say is even if you don’t have that snip data, go back and look at the tests.  If you’re tending to see high uncontrolled calcium, particularly if it’s not supported it all, and you’re tending to see low levels of phospholipids on UAA. Think about  the fact that PEMT may be an issue.  Consider Doug Quai and Black cohosh for some herbal support that may help to regulate the system.   We’re  doing a lot of work with chronic fatigue individuals on our site also. Chronic fatigue syndrome seems to be tied into mitochondrial dysfunction, we see a lot more chronic fatigue in females and this may relate to a lot of the roles of estrogen that we’ve just talked about. So again…aah…summarizing where we are and then we’ll take a little break while I upload the next set of slides so that we can look at the specifics of bacteria, what’s a gram-positive what’s a gram-negative? what’s an anaerobe? how do we know what we have, how do we deal with it?  Flowcharts to address it. Let’s just kinda  go back to where we started because it’s a lot of information.

We’re looking at the effects  aluminum and thallium  on the system. The role that bacteria play in retaining these metals in the body. The effect on mitochondrial energy, the role of estrogen on mitochondrial energy and the role of estrogen potential and mitochondria and chronic fatigue. The need to address oxidized species that are generated by the mitochondria as they make the energy you need to drive the reactions in your body.   The role that aluminum plays and Nickel  in generating additional oxidative species. That lack of methionine can play a role in your ability to deal with these species. Needing to bypass mutations in the methylation cycle to get those methionine   levels where we want them.  And then looking at the role of chronic bacteria and retaining metals in the body and in a few minutes we’ll look at how do we deal with that. So we’ll take a short break.

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