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Holistic Health & Nutrigenomic Profiling P3

Do they have the PowerPoint in like a book…?  they are on a CD okay.

I will probably upload these also by the way so that you don’t have to don’t go crazy trying to write everything down.

Okay so what we showing here is,  you’re not seeing much excretion here on urine toxic metal. As I spoke about this morning, when I am supplementing B12 and I’ve talked about this in the past but I’ll reiterate if briefly now. We are looking to see a black line of cobalt across the page when we have sufficient B12 in the system in my estimation.  Once we hit that black line across the page I’m looking to keep the B12 at the same high levels.  And I reiterate this because we had a question recently where a parent had a couple of B12 someplace  and said “Okay am I done, can I stop with B12 now?”.  No. Once we have this black line we want to keep that level of B12 in place, support with the antioxidants. I’m awaiting to see the black line go back to baseline while we still stay at the high levels of B12 support.  And so generally,  if I am seeing a black line across the page, at that point I’m expecting to see excretion.  But this UTM isn’t showing me much. And this UTM from the same individual isn’t showing much. So at this point we shift over to hair test  and fecal test during that same time period. Clearly we are getting excretion, we just weren’t seeing it via the  urine excretion tests. And similarly with the hair elements were seeing a lot of excretion, and so what I’m saying is look at a number of factors if you’re getting a UTM and you not seeing much and you are discouraged. Look at your UAA, see if you have markers that are indicating detox is going on.  Look at the cobalt levels see if you have sufficient B12 in place. If you do,  and you’re not seeing anything, it might be time to look at a different form of excretion, particularly as we’re talking about today.  If you’re dealing with gut microbes, if you’re working on the bacteria; if your secretory IGA levels are dropping,  I’m generally suggesting go do a fetal metal at that point because that might be where we’re seeing the excretion.  Alright, we are going to take a moment and then shift to Part Two.

 

Alright so we’re going to shift now specifically to aluminum.  Why I worry so much about aluminum, the relationship of aluminum to bacteria in the body.  But again just to take a moment and reiterate:  We want to pay attention to iron – even a little bit of iron is not a good thing as far as I’m concerned.

We want to pay attention to the genetics.  What snips are we dealing with? What do we need to bypass those snips?  What do we need to do about the general environment?  And we’re not just talking about aluminum as you just saw on those UTMs.  Any range of etals can be excreted. Now many of you have probably seen this particular slide before that steff,  but I don’t forget simply limited to steff will in fact retain and take up aluminum in the body. And based on some of the other references we just saw, I think you can be confident that a number of other bacteria can take up aluminum as well as other metals.

We know that long-term aluminum feeding can affect acetylcholine levels and there was worked on years ago looking at imbalances in acetylcholine levels in autism. Aahm… it inhibits the activity of acetyl cholinesterase, which means some of those acetylcholine levels can climb too high and some of the consequences acetyl cholinesterase inhibitions were seen most markedly in Gulf War Syndrome, but also in a number of other conditions.

Some of the kids who problems with tetanus toxin and reacted poorly to DPT’s. I’ll touch on that again briefly, because we’ve talked about it before and there’s a lot of new information I want to cover.  But looking at the effect aluminum may have to exacerbate some of these other issues.  And in terms of acetyl cholinesterase inhibitions some of the kinds of things you might see, including bladder issues, muscle weakness, and that in fact I think ties back very much so aluminum toxicity in the body.

Aahm, if we look at the effect of aluminum on oxidative stress. And I touched on this this morning in the doctors workshop but we’re gonna look at this probably in more detail than most if you want to in a few minutes.

The role the mitochondria in the body – The mitochondria are the energy center in your body. They are what help to drive reactions and transport and generate the energy you need.  But in doing so it creates oxygen radicals and oxidative stress, and your body needs to be in a position to offset the oxygen radicals that are generated from the mitochondria and balance that where certain compounds in the body that you really need such as glutathione, won’t stay in the reduced form.  If glutathione becomes oxidized it’s not going to give you what you need.  And so we’re looking at this balance between oxidative stress and oxygen generated for mitochondrial energy and needing to keep the system and balancing a reduced form.  And what can tip the scale is added pressure on the system from something like aluminum that can increase the oxidative stress on the body.

And so what we’re looking at here is, that the amount of oxidative damage that you’re seeing in the presence of aluminum, is a lot higher than if there’s no aluminum present. And if we look at the level of reduced glutathione, it’s lower than if there’s no aluminum present. And if we look at other species of glutathione, in the presence of aluminum versus the absence of aluminum you can see the difference.  And catalase, which is another enzyme in your body,  in the presence of aluminum versus the absence of the aluminum. So aluminum is having a direct effect on oxidative stress in the system, essentially making it worse and perhaps tipping the scales so that we can’t keep the body in the balance we need. And so we say that aluminum is causing oxidative damage basically. And it can promote biological oxidation, whether it’s in a test tube or in a body okay.  And so this is why we’re focusing so strongly on aluminum as well as those other metals and looking at that relationship between the bacteria in the body and the ability to hold onto that aluminum., which then tips the scales for the oxidative stress, so that instead of staying in balance,  we’re falling out of balance.

And the use of antioxidants – I am giving just this one example about how melatonin can play difference. And so if we look at in the presence of something like melatonin – this is your oxidized form of glutathione, and when you add melatonin, look at how that oxidizes form goes down okay. So let’s just look at this again.

Oxidized glutathione which is not the form that we want it  in. And once we add an antioxidant – in this case it’s melatonin – you can pull the level of that oxidized form down.  So we want to be very conscious of the antioxidants we’re adding and keeping that system in balance.

 

In the mitochondrial membrane, [00:36:35.24] the way that mitochondria generate energy is through this series of reactions that occurs in the membrane with the cytochromes. And when it’s generating this energy the ATP we need to drive reactions in the body, it also generates oxygen, okay. So it’s a series of reactions, that give us the energy we need we have to have this happen. But at the same time, it is generating oxygen that can create damage in the system. And then that is exacerbated in the presence of something like aluminum. And whether we look at melatonin or another antioxidant, its role is to help us to deal with these oxygen species and to be able to reduce things like glutivian back to the form we need.

NADH is another key intermediate that helps us to deal with oxidative damage.  And so just looking at it another way, if we’re looking at the energy  in that membrane, and I’m going to go back over that in a minute, particularly because it’s very tightly tied to the newest snip that’s been found for this voltage gated calcium snip in autism.  You’re looking at the energy potential to drive reactions, and if it’s a young individual, we have a high level of energy. As you age that goes down and that has a lot to do with oxidative stress. When we use an antioxidant such as melatonin we can get that energy potential, that energy generation in the membrane back to where things were in a younger individual.

Now it’s not just aluminum that can create additional oxidative stress.  Nickel can also cause that problem and often times I’ve mentioned in the past that we see excretion of nickel before we see excretion of mercury.  We’re not only interested in nickel as an indicator that mercury might flow next. But also the fact that we’ve got that much nickel in the system, how much more oxidative stress are we creating on top of that from aluminum.  As well as what’s naturally generated by mitochondrial function. [00:38:59.21]

 

Aahm…biofilms have been a hot topic in autism for a while, and if we look at the ability to form a biofilm, okay, if nutrients are depleted we’re going to have more biofilms but in the presence of oxidative stress the ability to form a biofilm is going to be a lot greater than in a mutation where you’ve removed the ability to form a biofilm, okay.

So to summarize so far, because I know it’s a lot of information in a short amount of time: Aluminum can contribute to oxidative stress,  mitochondria themselves generate  oxidative reactants.  There’s a Catch-22, we’ll get to that in a minute, of the effect  aluminum  on the TCA cycle, the energy cycle. Because aluminum inhibits points in the cycle as well as the fact that it increases oxidative stress. And so basically aluminum is helping to cripple the activity of the mitochondria in my opinion. And that’s part of the reason I think we see some of the seizure activity and low muscle tone when we have aluminum toxicity. Nickel can increase the effect of oxidative stress, we look at the positive role of melatonin and other antioxidants and again where our focus today is on the gut bugs, the role oxidative stress can have  on increasing the likelihood of having biofilms in the body, okay. So now,  going back to the effect… other effects of aluminum on the system in addition to oxidative stress.

 

We’ve talked about before the gluto aluminum interferes with much glutamate dehydrogenase. Why do we care about that?  If  we can’t move from glutamate to alpha ketoglutarate, we can’t feed into the Krebs cycle but now we’re stuck at glutamate. We’ve  talked about the consequences of excitotoxins and glutamate at length before.

Aluminum also inhibits the activity of  an enzyme that helps to regenerate BH4, and if you recall we need BH4 to make serotonin, we need BH4 to make Dopamine. So our neuro transmitters depend on BH4. Also adequate BH4 is necessary to be able to deal with oxygen radicals in a healthy way.  And so again another one of these Catch-22s. Aluminum creates havoc  such that we have more oxidative problems, and in addition it inhibits the enzyme that makes the compound that might help us to be able to deal with these oxidized species.

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