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Holistic Health & Nutrigenomic Profiling P2

­­­­­Okay so we’ve  talked about before that viruses and bacteria are two types of microbes you can have in your system.  And both of them can create a situation where you’re retaining metals in the body. Now focusing first on the bacterial issue in part three of this talk today we’ll talk about virus. Where is the bacteria coming from? It could be a maternal streptococci that is transmitted to the infants at birth. It could be related to SHMT, A129AC, AC18 mutations, decreased gut pH, antibiotic use, lack of normal flora, problems with gut pH and stomach acid related to lack of B12 and some of the mutations that require higher doses of B12 or SUOS’ lack of bile related to some of the other mutations;  methylation cycle mutations.  So if we don’t have a methylation cycle properly supplemented and we don’t have adequate immune responses, regulating what’s self, what’s non-self; what’s an invader and how do we react to it.

So starting first as I said with a role of iron. And we’re gonna go through this pretty quickly because the bottom line is iron increases bacterial virulence.  As I spoke about in the doctors workshop this morning when I’m looking at a UEE I don’t want to see any iron on the UEE. If I see iron I am suspecting an SMHMT plus situation that I’m going to find that snip.  Sometimes however we’re not SMHMT plus, but we are seeing iron on the UEE and just know that that iron can increase bacterial virulence. And so what you got your number of references supporting the fact that iron does in fact increase bacterial virulence. And some specifics that a lot of the types of bacteria that we’re used to seeing and having problems with whether it’s strap, whether it’s eccoli,  whether it’s staf…aahm…Pseudomonas,  that iron increases bacterial virulence.

Clostridia which is such a problem for so many other children.  Even parasites; and you’ll notice when you start to run some of the DNA stool tests that a lot of those same kids who’re coming up positive for anaerobes are also coming up positive for parasites.  So we’re looking at this interaction between iron, microbes and the SHMT status.

Now Ferritin is a compound in the body that helps your body to move iron around and hold on to it properly. Work has shown that there is a connection between ferritin and the ability of your body to take in and use foliates and also to help to regulate certain aspects of the methylation cycle in particular the SHMT mutation. And so what we find is that when we have high levels of iron it increases the activity of this enzyme. And the net result is to pull the cycle that methylation cycle we looked at earlier away from the production of methionine. And we’ll talk about methionine a lot today and the central role that it has in helping to reduce oxidative stress. Pulling you away from methionine, away from some of the other intermediates like SAMe and the other building blocks that we need and towards this portion of the pathway which is going to increase thymidine synthesis, but decrease your level of SAMe, decrease your level of  5 methyl THF. If you’ll remember if you have a C6 717 mutation we’re already having trouble generating that, or if we have some of the MTR – MTR are mutations – we’re having trouble moving from five methyl THF to mathianine.  And so when we have iron present. Especially in addition to an SHMT plus status we’re shunting our cycle towards this portion of the pathway and away from some of the areas where we need  for healthy function of the system.

And so what you want to be looking for is even subtle levels of iron on a UEE. And so it doesn’t have to be a lot, but if we are seeing SHNT plus any iron on one of these tests is something that I’m looking out for. Also something that I mentioned this morning in the doctors workshop,  if you’re looking at seeing even just a very low-level of iron, but your creatinine level is high remember that the creatinine level is the number you’re dividing all of your values by on one of these tests. So if your creatinine is sitting up around 150 you’re dividing by a big number, therefore even a little bit of iron is more meaningful because if you creatinine were down at 25 like we will see on some of other tests later, you’ll be  dividing by a much smaller number and that value would be higher.

Again we’re look at the SHNT plus and we’re seeing iron. And again…and what I will try to do today as I hit you with a lot of scientific information is,  interspersed with  data,  to break it up a little bit but also to give you something you’re familiar with and that you used to looking at so that you can be looking at your own test at home and seeing if you see some of these patterns again. Okay so just emphasizing to you the importance of iron and  virulence looking for iron on  your urine essential aliment test especially if you have an SHNT plus status. But even if you don’t,  you want to be looking for iron because if  we’ve  got iron; I am concerned about gut bugs.   If we are seeing iron on a UEE , I want to see a CSA to see what’s going on in the gut.

Okay, so SHMT plus may relate to iron levels.  Iron can relate virulence and the bacterial load.  So now we’re going to look at the role of this increased bacterial load on metal accumulation in the body, how it plays a role. And again if we’re seeing iron or SHMT plus I’m worried about what’s going on in the gut, run a CSA or a similar test. Sometimes I’ll get a file and the CSA test in there is two or three years old. I think that’s way too long to wait for new test.  I mean frankly I think people should to be running CSA tests and,  if needed,  DNA stool test at the very least once a year, more likely at least twice year or more often than that. The role of these bacteria in the body is so critical and knowing what you’ve got and knowing whether or not you’ve pulled that load down, you don’t want to just assume that everything is static for three years or even a year frankly. [00:21:36.23] Interviewer:

 

So uptake of metals by bacteria.  A lot this work was done years ago looking at the ability to use bacteria to break down oil spill.  Some of the original work was done it got to be 20 years ago by (Inaudible)… GE, looking at the ability of bacteria to break down oil spills. And so much of that data supporting and proving that bacteria do in fact accumulate metals comes from some of the environmental work. And if we look at the number of different bacteria and the different types of metals that they can accumulate and the different mechanisms that they have to retain metals in the body, you can start to see why I keep going back to this “look at the gut, let’s get the gut clean”, because if we’ve got a swamp and we got bacteria in that swamp we are going to be having metals.  And if you look at just the different ways that the bacteria have to hold onto all these metals in the body, sometimes people will say to me “Well, where the metal coming from?”   Well they are coming from inside.  That every one of these UTMs,  fecal metals,  hair metals that you’re seeing, these are metals that are trapped in the body helping to create havoc and the goal is get them out and part of the way to get them out is to be able to address these microbes in the system.

 

We can even look at…I mean…you’re looking at pictures of Pseudomonas that’s actually accumulated heavy metals. These are electro micrographs to show you bacteria retaining metals within them. Okay.  And it’s not just… you know whether it’s lead… whether it’s aluminum and we’ll talk a lot more about aluminum later, but many of these metals that you’re seeing excreted on the urine toxic metal tests in fact you can actually see these organisms holding onto metals. Okay.  And it’s scary to think that when you look at a CSA  and can you see pseudomonas of four plus, and we’ll look at how we address some of that in the next talk, that this may be part of what’s going on in the body.  That…that it’s just not “Oh there’s some bacteria but”… but it’s a much more complex and dangerous situation.  I mean you know just look at the amount metal in some of these microbes.  Okay.

 

So if we look at the relationship between lead accumulation and bacterial concentration… I mean it is definitely suggesting that bacteria interact with metals in the body.  And in the next part of the talk we are going to look at the structure of bacteria,  the difference between a gram-positive and a gram-negative bacteria; how they can hold onto metals differently and what different approaches we need to take to address the different types of bacteria.

 

And again just reiterating the point that heavy-metal accumulation by bacteria, the organisms and the kinds of metals that are proven to hang onto and in some cases up to 50% of the driveway to these bacteria can be heavy metals.

If we talk about gram-positive bacteria, many of you may not know the difference between a gram-positive and a gram-negative right now, but in another hour so you will.  And they have a very thick outer surface to them and that can easily (inaudible) [00:26:36.52] and hold on to metals.  Gram-negatives have two layers and though the metals there can get trapped in between those layers almost like a sandwich.  And so the techniques that we are using to address gram-positive versus gram-negative are not identical.  And I’ll give you some flowcharts later in the PowerPoint presentation so that you have some tools to be able to know again  how do we address specifically what we’re seeing.  So we’re worried about the genetics which we’re glossing over today, but we’ve talked about before there is PowerPoints about them before; the new book we will go over it and the workbook goes over it.  There’s the gut environment that I’ve talked about at length, but the swamp we want to clean up and then our focus today is specifically the gut microbes.

What do we have?

How do we identify it?

What do we do about it?

And why do we care?  And part of the reason we care is because of the ability to have metals in the system even to levels approaching 50% of the dry weight of the bacteria.

What we see clinically agrees with the concept that addressing bacterial issues can relate to the release of metals in the body okay. So we’re going to run through some tests that look familiar to you so that I don’t overload you with information but also to give you a reference point to be able to go back and look at your own tests. And look for some of what we’re talking about.  And so whether it’s lead, or mercury or cadmium, or thallium a tungsten – we talked a lot about thallium this morning in the doctors workshop with respect to ATP, and we’ll talk about that more  in terms of mitochondrial function pretty soon.

Again more cadmium, thallium so just a range of metals and I won’t belabor the point, just a visual that as you address the microbes in the body you can see excretion of metals from the system and most of the examples I just gave you were UTMs. For some individuals if you’re not seeing that excretion on UTM, and particularly if you’re seeing indications on UAA that perhaps detox is going on.  Then go to fecal metal, go to a hair test if the secret Tori IGA levels are very low on your CSA then at that point you might want to look at a fecal metal also.

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